Campfield L A, Smith F J, Burn P
Department of Metabolic Diseases, Hoffmann-La Roche Incorporated, 340 Kingsland Street, Nutley, NJ 07110, USA.
Science. 1998 May 29;280(5368):1383-7. doi: 10.1126/science.280.5368.1383.
Obesity is an increasingly prevalent and important health problem. Although treatment is available, the long-term maintenance of medically significant weight loss (5 to 10 percent of initial body weight) is rare. Since 1995 there has been an explosion of research focused on the regulation of energy balance and fat mass. Characterization of obesity-associated gene products has revealed new biochemical pathways and molecular targets for pharmacological intervention that will likely lead to new treatments. Ideally, these treatments will be viewed as adjuncts to behavioral and lifestyle changes aimed at maintenance of weight loss and improved health.
肥胖是一个日益普遍且重要的健康问题。尽管有治疗方法，但医学上显著的体重减轻（初始体重的5%至10%）的长期维持却很少见。自1995年以来，专注于能量平衡和脂肪量调节的研究呈爆发式增长。肥胖相关基因产物的表征揭示了新的生化途径和药物干预的分子靶点，这可能会带来新的治疗方法。理想情况下，这些治疗方法将被视为旨在维持体重减轻和改善健康的行为及生活方式改变的辅助手段。
