脂质体悬浮液以及[具体物质1]和[具体物质2]提取物在喂食高热量饮食的小鼠模型中的抗肥胖作用

Anti-Obesity Effect of Liposomal Suspension and Extracts of and in a Murine Model Fed a Hypercaloric Diet.

作者信息

Palomo-Martínez Luis Edwardo, Paniagua-Castro Norma, Escalona-Cardoso Gerardo Norberto, Leyva-Daniel Diana E, Ibañez-Hernández Miguel A A, Cruz-Narvaez Yair, Alamilla-Beltrán Liliana

机构信息

Instituto Politécnico Nacional, Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Av. Wilfrido Massieu 399, U. P. Adolfo López Mateos, Gustavo A. Madero 07738, Mexico.

Instituto Politécnico Nacional, Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Av. Wilfrido Massieu 399, U. P. Adolfo López Mateos, Gustavo A. Madero 07738, Mexico.

出版信息

Nutrients. 2025 Jul 9;17(14):2275. doi: 10.3390/nu17142275.

DOI:10.3390/nu17142275

PMID:40732899

Abstract

BACKGROUND/OBJECTIVES: Obesity is the primary risk factor for the development of chronic degenerative diseases. Multidisciplinary treatments target multiple pathologies associated with obesity. In this study, a potential adjuvant therapy was evaluated by combining extracts from Hibiscus and . These extracts were used in both a simple and liposomal suspension, the latter aimed at enhancing the activity of phenolic compounds and determining various metabolic benefits.

METHODS

In this research, the use of biotechnological approaches for the development of a liposomal suspension formulation with appropriate characteristics of stability, particle size, polydispersity index, concentration, and zeta potential induced an effective reduction in body weight and epididymal fat in a murine obesity model over 8 and 45 days.

RESULTS

Treatment with the liposomal suspension reduced variables in the lipid profile, aspartate aminotransferase activity, and energy expenditure, while also promoting an increase in locomotor activity.