Baum J L
Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976 Jul-Aug;81(4 Pt 1):OP619-23.
KCS in man is often associated with a systemic disease whose pathogenesis is still obscure. A spontaneous animal model resembling Sjögren's syndrome has been developed in the NZB and NZB-NZW mouse. Other spontaneous animal models analagous to lupus erythematosis and polyarteritis have been found in dogs and Aleutian mink, respectively. Studies of the eyes and lacrimal glands in such animals, and in dogs with distemper, should be pursued. A viral etiology is implicated in each of the models. The roles of both the main and accessory lacrimal glands in normal and KCS eyes have been discussed, as well as drug-induced KCS and opportunities for its further investigation and treatment.
人类的角结膜干燥症通常与一种发病机制仍不清楚的全身性疾病有关。在新西兰黑鼠和新西兰黑鼠 - 新西兰白鼠杂交鼠中已培育出一种类似于干燥综合征的自发动物模型。分别在犬类和阿留申水貂中发现了类似于红斑狼疮和结节性多动脉炎的其他自发动物模型。应该对这类动物以及患犬瘟热的犬类的眼睛和泪腺进行研究。在每个模型中都涉及病毒病因。已经讨论了主泪腺和副泪腺在正常眼和角结膜干燥症眼中的作用，以及药物诱导的角结膜干燥症及其进一步研究和治疗的机会。
