MacLeay J M, Wilson J H
Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
J Am Vet Med Assoc. 1998 May 15;212(10):1597-9.
A 14-year-old Arabian mare was admitted for lethargy, anorexia, and low fecal output. On the basis of laboratory, physical examination, and electrocardiographic findings, diagnoses of type-II renal tubular acidosis (RTA), impaction of the large colon, and ventricular tachycardia were made. Diagnosis of type-II RTA was based on measurement of a low fractional excretion value for potassium and fractional excretion value for sodium within the reference range. In contrast, horses with type-I RTA have high fractional excretion values for sodium and fractional excretion values for potassium within reference ranges. Treatment consisted of intravenous and oral administration of sodium bicarbonate, intravenous administration of fluids, and oral administration of mineral oil and docusate sodium. Acidosis improved, and ventricular tachycardia resolved with resolution of acidosis. Oral administration of bicarbonate was continued after discharge. The mare had several relapses, which were associated with anorexia and low intake of supplemental bicarbonate. The mare was found dead 2 months after discharge.
一匹14岁的阿拉伯母马因嗜睡、厌食和低粪便排出量入院。根据实验室检查、体格检查和心电图检查结果，诊断为II型肾小管酸中毒（RTA）、大肠阻塞和室性心动过速。II型RTA的诊断基于钾的低分数排泄值和钠的分数排泄值在参考范围内。相比之下，I型RTA的马匹钠的分数排泄值和钾的分数排泄值在参考范围内较高。治疗包括静脉和口服碳酸氢钠、静脉补液以及口服矿物油和多库酯钠。酸中毒得到改善，室性心动过速随着酸中毒的缓解而消失。出院后继续口服碳酸氢盐。这匹母马复发了几次，均与厌食和补充碳酸氢盐摄入量低有关。这匹母马在出院2个月后被发现死亡。
