离子强度对来自太阳海葵的细胞溶素——刺参溶素I溶血活性增强的作用。
The role of ionic strength on the enhancement of the hemolytic activity of sticholysin I, a cytolysin from Stichodactyla helianthus.
作者信息
Alvarez C, Lanio M E, Tejuca M, Martínez D, Pazos F, Campos A M, Encinas M V, Pertinhez T, Schreier S, Lissi E A
机构信息
Departamento de Bíochímica, Facultad de Biología, Universidad de La Habana, Cuba.
出版信息
Toxicon. 1998 Jan;36(1):165-78. doi: 10.1016/s0041-0101(97)00069-x.
Sticholysin I (St I) is a potent cytolytic polypeptide purified from the Caribbean sea anemone Stichodactyla helianthus. The hemolytic activity of sticholysin is potentiated by its preincubation at high ionic strengths. In the present work the mechanism of the potentiating action of the medium ionic strength on the toxin hemolytic capacity is investigated. It is suggested that preincubation with high saline concentration induces a transition of St I to a more relaxed conformation that facilitates the lytic process.
刺参溶素I（St I）是一种从加勒比海海葵日光海葵中纯化得到的强效细胞溶解多肽。刺参溶素的溶血活性在高离子强度下预孵育后会增强。在本研究中，我们研究了中等离子强度对毒素溶血能力的增强作用机制。结果表明，高盐浓度预孵育会诱导St I转变为更松弛的构象，从而促进溶解过程。
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