Cerecetto H, Di Maio R, Ibarruri G, Seoane G, Denicola A, Peluffo G, Quijano C, Paulino M
Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Farmaco. 1998 Feb;53(2):89-94. doi: 10.1016/s0014-827x(97)00011-6.
Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti-trypanosomal agents. The compounds were prepared in good to excellent yields in 2-3 steps from readily available starting materials. Some derivatives were found to be active against Trypanosoma cruzi with an activity similar to that of Nifurtimox.
从5-硝基-2-糠醛或5-硝基噻吩-2-甲醛制备了几种新型氨基脲衍生物，并作为潜在的抗锥虫剂进行了体外测试。这些化合物由易得的起始原料经2-3步反应制备，产率良好至优异。发现一些衍生物对克氏锥虫有活性，其活性与硝呋替莫相似。
