卡马西平对暴露于高温环境的大鼠细胞色素P4502B1/2B2的影响。
Effect of carbamazepine on cytochromes P4502B 1/2B2 in rats exposed to high environmental temperature.
作者信息
Kobylińska K, Pachecka J
机构信息
Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Poland.
出版信息
Acta Pol Pharm. 1997 Nov-Dec;54(6):447-9.
PMID:9604694
Abstract
The combined effect of carbamazepine (CBZ) and raised environmental temperature on total hepatic cytochrome P450 and on cytochromes P4502B1/2B2 contents was investigated. Carbamazepine produced significant increase of the contents of total cytochrome P450 and cytochromes P4502B1/2B2 in rats exposed to 21 degrees C and 28 degrees C. In contrast exposure of rats of 35 degrees C decreased induction capacity of carbamazepine.
摘要
研究了卡马西平（CBZ）与环境温度升高对肝脏总细胞色素P450以及细胞色素P4502B1/2B2含量的联合影响。卡马西平使暴露于21摄氏度和28摄氏度环境中的大鼠的总细胞色素P450以及细胞色素P4502B1/2B2含量显著增加。相比之下，暴露于35摄氏度环境中的大鼠，卡马西平的诱导能力降低。
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