烟酰胺增强甲氨蝶呤对小鼠胶原II诱导性关节炎的疗效。
Enhancement of the effect of methotrexate on collagen II induced arthritis in mice by nicotinamide.
作者信息
Kröger H, Hauschild A, Ohde M, Thefeld W, Krüger D, Bache K, Ehrlich W
机构信息
Deutsches Rheumaforschungszentrum Berlin, Germany.
出版信息
Inflammation. 1998 Jun;22(3):277-85. doi: 10.1023/a:1022348132132.
Treatment with a combination of 10 mg/kg i.p. methotrexate and 100 mg/kg i.p. nicotinamide inhibits the development of collagen II induced arthritis in male DBA/1 X B.10(4R) mice, as assessed by the arthritic index and whole blood chemiluminescence. The effect is much more pronounced than with either methotrexate or nicotinamide alone at the same concentrations. Determination of GOT and GPT levels in the blood revealed that the treatment causes no toxic side effects on the liver.
腹腔注射10 mg/kg甲氨蝶呤和100 mg/kg烟酰胺的联合治疗可抑制雄性DBA/1 X B.10(4R)小鼠中由II型胶原蛋白诱导的关节炎的发展，这是通过关节炎指数和全血化学发光评估得出的。在相同浓度下，该联合治疗的效果比单独使用甲氨蝶呤或烟酰胺更为显著。血液中谷草转氨酶（GOT）和谷丙转氨酶（GPT）水平的测定表明，该治疗对肝脏没有毒性副作用。
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