Ehrlich A, Basse H, Henkel-Ernst J, Hey B, Menthe J, Lücker P W
Medical Department Phase I, Institut für Klinische Pharmakologie Bobenheim, Grünstadt, Germany.
Methods Find Exp Clin Pharmacol. 1998 Mar;20(2):155-61. doi: 10.1358/mf.1998.20.2.485656.
The gastric irritation potential of orally administered coffee (150 ml) was investigated in four healthy volunteers by continuous measurement of gastric potential difference (GPD) and intragastric pH. Furthermore, serum gastrin concentrations were measured up to 45 min after administration of the coffee. One of the coffees, untreated, had to be compared with a pretreated coffee. The evaluation of the target parameters Reiz-Index, AUB, Pdmax and ttot revealed a significant difference between untreated coffee and specially treated coffee: the improved coffee processing produced significantly less mucosal irritation. Regarding the intragastric pH, no significant differences between the treatments were observed and no stimulation of gastric acid secretion following coffee was measurable. No consistent effect on serum gastrin concentration was seen: two of the four subjects had a steep increase in serum gastrin following administration with a clear difference between the differently processed coffees, whereas the other two subjects showed no change in serum gastrin. The results of this pilot study confirm the findings of former experiments on the reliability of continuous transmural GPD measurement when investigating the mucosal irritation potential of barrier breakers.
通过连续测量胃电位差（GPD）和胃内pH值，对4名健康志愿者口服150毫升咖啡后的胃刺激潜力进行了研究。此外，在饮用咖啡后长达45分钟内测量血清胃泌素浓度。其中一种未处理的咖啡必须与预处理咖啡进行比较。对目标参数刺激指数、AUB、Pdmax和ttot的评估显示，未处理咖啡和经过特殊处理的咖啡之间存在显著差异：改进后的咖啡加工对黏膜的刺激明显减少。关于胃内pH值，各处理之间未观察到显著差异，且饮用咖啡后未检测到胃酸分泌的刺激。对血清胃泌素浓度未观察到一致的影响：四名受试者中有两名在饮用后血清胃泌素急剧上升，不同加工的咖啡之间存在明显差异，而另外两名受试者的血清胃泌素没有变化。这项初步研究的结果证实了以前实验的结果，即在研究屏障破坏剂的黏膜刺激潜力时，连续经壁GPD测量的可靠性。
