磷脂酰肌醇3激酶调节亚基（p85α）的变异体：初步证据表明该变异体在皮马族女性的急性胰岛素反应和2型糖尿病中可能发挥作用。 - Suppr

Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women.

作者信息

Baier L J, Wiedrich C, Hanson R L, Bogardus C

机构信息

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.

出版信息

Diabetes. 1998 Jun;47(6):973-5. doi: 10.2337/diabetes.47.6.973.

DOI:10.2337/diabetes.47.6.973

PMID:9604878

Abstract

摘要

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Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women.磷脂酰肌醇3激酶调节亚基（p85α）的变异体：初步证据表明该变异体在皮马族女性的急性胰岛素反应和2型糖尿病中可能发挥作用。

Diabetes. 1998 Jun;47(6):973-5. doi: 10.2337/diabetes.47.6.973.

In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity.磷脂酰肌醇3激酶人类p85α调节亚基天然存在变体的体外和体内研究：对蛋白激酶B的抑制作用及其与2型糖尿病、胰岛素分泌、葡萄糖消失常数和胰岛素敏感性的关系

Diabetes. 2001 Mar;50(3):690-3. doi: 10.2337/diabetes.50.3.690.

Variants in the Ca V 2.3 (alpha 1E) subunit of voltage-activated Ca2+ channels are associated with insulin resistance and type 2 diabetes in Pima Indians.电压激活钙通道的Ca V 2.3（α1E）亚基中的变异与皮马印第安人的胰岛素抵抗和2型糖尿病相关。

Diabetes. 2007 Dec;56(12):3089-94. doi: 10.2337/db07-0587. Epub 2007 Aug 24.

Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index.磷脂酰肌醇3激酶p85α调节亚基中常见氨基酸多态性的鉴定：对葡萄糖消失常数、葡萄糖效能和胰岛素敏感性指数的影响。

Diabetes. 1997 Mar;46(3):494-501. doi: 10.2337/diab.46.3.494.

A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes.PPP1R3中的一种常见变异与胰岛素抵抗和2型糖尿病相关。

Diabetes. 1998 Sep;47(9):1519-24. doi: 10.2337/diabetes.47.9.1519.

Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians.位于1号染色体q臂上与2型糖尿病连锁的候选基因ARHGEF11中的变异，在皮马印第安人中与胰岛素抵抗和2型糖尿病存在名义上的关联。

Diabetes. 2007 May;56(5):1454-9. doi: 10.2337/db06-0640. Epub 2007 Feb 7.

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.钙蛋白酶-10基因多态性与肌肉mRNA水平降低及胰岛素抵抗相关。

J Clin Invest. 2000 Oct;106(7):R69-73. doi: 10.1172/JCI10665.

Insulin resistance in the pathogenesis of NIDDM in Pima Indians.

Diabetes Care. 1993 Jan;16(1):228-31. doi: 10.2337/diacare.16.1.228.

Linkage analysis of acute insulin secretion with GLUT2 and glucokinase in Pima Indians and the identification of a missense mutation in GLUT2.

Diabetes. 1994 Apr;43(4):558-63. doi: 10.2337/diab.43.4.558.

Variations in the vitamin D-binding protein (Gc locus) are associated with oral glucose tolerance in nondiabetic Pima Indians.维生素D结合蛋白（Gc基因座）的变异与非糖尿病皮马印第安人的口服葡萄糖耐量有关。

J Clin Endocrinol Metab. 1998 Aug;83(8):2993-6. doi: 10.1210/jcem.83.8.5043.

引用本文的文献

Pancreatic endocrine and exocrine signaling and crosstalk in physiological and pathological status.胰腺内分泌和外分泌信号传导以及生理和病理状态下的相互作用。

Signal Transduct Target Ther. 2025 Feb 14;10(1):39. doi: 10.1038/s41392-024-02098-3.

Insulin receptor signaling in normal and insulin-resistant states.胰岛素受体信号转导在正常和胰岛素抵抗状态下的作用。

Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1):a009191. doi: 10.1101/cshperspect.a009191.

Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population.磷脂酰肌醇3-激酶p85α调节亚基基因PIK3R1单倍型与女性双胞胎群体的体脂和血清瘦素相关。

Diabetologia. 2006 Nov;49(11):2659-67. doi: 10.1007/s00125-006-0388-z. Epub 2006 Sep 20.

Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study.调节早期胰岛素信号通路的基因中的常见多态性：对体重变化及从糖耐量受损向2型糖尿病转化的影响。芬兰糖尿病预防研究。

Diabetologia. 2004 May;47(5):871-7. doi: 10.1007/s00125-004-1395-6. Epub 2004 May 1.

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.2型糖尿病的候选基因关联研究表明，参与β细胞功能以及胰岛素作用的基因发挥了作用。

PLoS Biol. 2003 Oct;1(1):E20. doi: 10.1371/journal.pbio.0000020. Epub 2003 Oct 13.

Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.胰岛素信号通路中的基因变异性可能会增加晚发性阿尔茨海默病的发病风险。

J Neurol Neurosurg Psychiatry. 2002 Sep;73(3):261-6. doi: 10.1136/jnnp.73.3.261.

Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha.磷脂酰肌醇3激酶p85α的Met326Ile变体的特征分析

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2124-8. doi: 10.1073/pnas.042688799. Epub 2002 Feb 12.

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Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women.

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