Konovalova N P, Volkova L M, Tatyanenko L V, Kotelnikova R A, Yakushchenko T N, Kagiya T V
Institute of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region.
Neoplasma. 1997;44(6):361-5.
A triazole group radiosensitizer AK-2123 is shown to inhibit considerably the growth of hepatic metastases induced by the intrasplenic injection of colon adenocarcinoma cells in syngenic mice. Even an extremely low dose of the drug exhibits the antimetastatic effect. It is shown that AK-2123 injected at therapeutic dose inhibits active transport of calcium ions by the (Ca2+-Mg2+)-dependent ATP-ase. The antimetastatic effect of AK-2123 is suggested to be related, at least partially, to the inhibition of the active calcium transport.
三唑类放射增敏剂AK - 2123被证明能显著抑制同基因小鼠脾内注射结肠腺癌细胞诱导的肝转移瘤生长。即使是极低剂量的该药物也具有抗转移作用。结果表明，以治疗剂量注射的AK - 2123可抑制（Ca2 + - Mg2 +）依赖性ATP酶对钙离子的主动转运。AK - 2123的抗转移作用至少部分与抑制钙离子主动转运有关。
