Daif A K, Al-Rajeh S, Awada A, Al Bunyan M, Ogunniyi A, AbdulJabar M, Al Tahan A R
Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Eur Neurol. 1998;39(3):182-6. doi: 10.1159/000007931.
We studied 89 MS patients comprising 38 males and 51 females seen over a 10-year period. The hospital frequency was 25/100,000 patients. The diagnosis was mainly clinical and was supported by neuroimaging, cerebrospinal fluid analysis and neurophysiological tests. Sixty-five patients (73%) were Saudis and the peak age of onset was in the third decade. Fifty-two patients (58.4%) had clinically definite MS, 17 (19.1%) had laboratory-supported definite MS, 15 (16.9%) were clinically probable MS cases and the remaining 5 (5.6%) had laboratory-supported probable MS. The mean age at onset of Saudi patients (25.9 years) was lower than that of the non-Saudis (29.4 years; p < 0.001). Involvement of the pyramidal system was the commonest mode of presentation. The clinical course was relapsing-remitting in 60.7%, progressive-relapsing in 20.2% and primary progressive in 19.1%. The number of systems involved was significantly associated with the duration of disease (p < 0.001). The demographic features and the variability of clinical presentation of Saudi MS patients is similar to the results from neighbouring countries. Combination of clinical features and paraclinical tests is essential for accurate determination of extent of dissemination and for unmasking clinically silent lesions.
我们研究了89例多发性硬化症（MS）患者，其中包括在10年期间就诊的38名男性和51名女性。医院就诊频率为每10万名患者中有25例。诊断主要基于临床症状，并得到神经影像学、脑脊液分析和神经生理学测试的支持。65名患者（73%）为沙特人，发病高峰年龄在第三个十年。52名患者（58.4%）患有临床确诊的MS，17名（19.1%）患有实验室支持的确诊MS，15名（16.9%）为临床疑似MS病例，其余5名（5.6%）患有实验室支持的疑似MS。沙特患者的平均发病年龄（25.9岁）低于非沙特患者（29.4岁；p<0.001）。锥体系统受累是最常见的表现形式。临床病程中，复发缓解型占60.7%，进展复发型占20.2%，原发进展型占19.1%。受累系统的数量与疾病持续时间显著相关（p<0.001）。沙特MS患者的人口统计学特征和临床表现的变异性与邻国的结果相似。临床特征和辅助检查的结合对于准确确定病变播散程度和发现临床无症状病变至关重要。
