Dlusskaia I G, Ushakov I B
Aviakosm Ekolog Med. 1998;32(1):44-9.
Proposed are new quantitative criteria of the functional state of erythrocytes based on automated recording parameters of the acid hemolysis erythrogram. Extended analysis of adaptation of the red blood system in rats exposed to ionizing radiation (60CO, 1.25 MeV, 0.5, 1.0, and 6.0 Gy) pointed out that the normally existing stimulating effect of diuretic products on accumulation of juvenile cellular forms was not changed by the dose of 0.5 Gy but ceased after exposure to higher doses. A distinct interrelation (r = 0.83 and 0.61 at p < 0.003, respectively) was revealed between the number of low-resistant erythrocytes (EZR) and subsequent (4 to 7 days later) amount of reticulocytes in the norm and following exposure to 0.5 Gy of ionizing radiation. After exposure to 1.0 Gy and 6.0 Gy r values were below 0.3 at p > 0.2. A "reference cascade" of regression equations on the order of Rt = a + b x EZR could be developed for individual evaluation of different stages of impairment of one of the normal regulatory mechanisms of hemopoiesis in humans systematically exposed to ionizing radiation.
基于酸溶血红细胞图的自动记录参数，提出了红细胞功能状态的新定量标准。对暴露于电离辐射（60Co，1.25 MeV，0.5、1.0和6.0 Gy）的大鼠红细胞系统适应性的扩展分析指出，利尿剂产品对幼稚细胞形式积累的正常刺激作用在0.5 Gy剂量下未改变，但在暴露于更高剂量后停止。在正常情况下以及暴露于0.5 Gy电离辐射后，低抗性红细胞（EZR）数量与随后（4至7天后）网织红细胞数量之间存在明显的相互关系（分别为r = 0.83和0.61，p < 0.003）。暴露于1.0 Gy和6.0 Gy后，r值在p > 0.2时低于0.3。可以建立一个回归方程的“参考级联”，形式为Rt = a + b x EZR，用于系统暴露于电离辐射的人类造血正常调节机制之一受损不同阶段的个体评估。
