[Wistar大鼠和奥古斯特大鼠多巴胺系统功能亢进时中枢神经系统的比较细胞化学研究]
[Comparative cytochemical study of the central nervous system in Wistar and August rats in dopamine system hyperfunction].
作者信息
Sergutina A V
机构信息
Laboratory of Cytochemistry, Russian Academy of Medical Sciences, Moscow.
出版信息
Morfologiia. 1998;113(1):51-3.
Peculiarities of the CNS response to chronic treatment with L-DOPA were revealed by quantitative cytochemical methods in August (stress-sensitive) and Wistar (emotionally resistant) rats. In August rats L-DOPA administration caused aminopeptidase activity increase in sensomotor cortex layer 3 and nucleus accumbens, glutamate dehydrogenase activity growth in nucleus accumbens as well as the elevation of monoaminoxidase (MAO) activity in nucleus caudatus and nucleus accumbens (serotonin as substrate) and in nucleus caudatus and hippocampus (tryptamine as substrate), while acetyl cholinesterase activity did not change at all. At the same time in Wistar rats only glutamate dehydrogenase activity increase was observed in nucleus caudatus and nucleus accumbens.
采用定量细胞化学方法，在八月龄（应激敏感型）和Wistar（情绪抵抗型）大鼠中揭示了中枢神经系统对长期左旋多巴治疗的反应特点。在八月龄大鼠中，给予左旋多巴导致感觉运动皮层第3层和伏隔核的氨肽酶活性增加，伏隔核中的谷氨酸脱氢酶活性增强，以及尾状核和伏隔核（以血清素为底物）、尾状核和海马体（以色胺为底物）中的单胺氧化酶（MAO）活性升高，而乙酰胆碱酯酶活性则完全没有变化。与此同时，在Wistar大鼠中，仅观察到尾状核和伏隔核中的谷氨酸脱氢酶活性增加。
Zotero 插件