[Physico-chemical bases of the mechanism of thermal inactivation of the foot-and-mouth disease virus].
作者信息
Ponomarev A P, Andreeva O G
出版信息
Vopr Virusol. 1998 Mar-Apr;43(2):86-90.
PMID:9606878
Abstract
Experiments demonstrated that the effect of water activity on the solvate complex of virions underlies the mechanism of thermal inactivation of the foot and mouth disease virus in suspension; changes in the structure of the complex impair the electrophysical balance of the RNA-protein relations and hence, destroy the virus. Heating of virus-containing suspensions at moderate positive temperatures leads to destruction of the noninfectious part of virus population of 146S particles, thus decreasing the infectious activity of the virus.
摘要
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