Elledge S J, Harper J W
Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA.
Biochim Biophys Acta. 1998 Apr 17;1377(2):M61-70. doi: 10.1016/s0304-419x(98)00005-5.
In addition to the examples mentioned above, other important regulators of cell proliferation such as cyclin D, cyclin E, p21, p27 are all potentially controlled by ubiquitin-mediated proteolysis. In several of these, phosphorylation has been shown to play a role in targeting the proteins for degradation. It remains to be seen how important the SCF pathway and ubiquitin-mediated proteolysis, in general, will become in cancer research. However, it appears that we have only just scratched the surface on the role of these pathways in the control of important regulatory genes. We suspect there will be much more to come from analysis of these fascinating pathways.
除上述例子外，其他重要的细胞增殖调节因子，如细胞周期蛋白D、细胞周期蛋白E、p21、p27，都可能受泛素介导的蛋白水解作用调控。其中有几种情况已表明，磷酸化在促使蛋白质降解方面发挥作用。一般而言，SCF途径和泛素介导的蛋白水解作用在癌症研究中将变得多么重要，还有待观察。然而，看来我们对于这些途径在重要调控基因控制中的作用，才刚刚触及皮毛。我们怀疑，对这些迷人途径的分析将会带来更多发现。
