Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin.

BACKGROUND

Photodynamic therapy (PDT) has been shown to be an effective treatment modality for surface-oriented neoplasms of the skin, respiratory, gastrointestinal, and urogenital systems. The purpose of our study was to assess the safety and efficacy of PDT using Photofrin in the treatment of squamous cell carcinomas of feline facial skin.

MATERIALS AND METHODS

Cats with naturally occurring squamous cell carcinomas of the skin were entered into the study. PDT was delivered to the tumors using an argon-pumped dye laser 48 hours after the administration of the photosensitizer porfimer sodium (Photofrin). Following treatment, the tumors were evaluated for complete response rates and local control durations.

RESULTS

Eight tumors were staged T1a, 9 staged T1b, and 14 staged T2b. Complete response rates as well as local control durations were significantly related to stage (p < 0.0001). Complete response was achieved in 100% of the T1a tumors and 53% of the T1b tumors; the overall 1-year local control rate for all treated tumors was 62%. Clinical, hematological, and biochemical evidence of toxicity was not seen in any cat following drug administration.

CONCLUSION

PDT with the photosensitizer Photofrin was safe and effective in treating early stage squamous cell carcinomas of the feline skin.