人乳腺癌中的组胺
Histamine in human breast cancer.
作者信息
Reynolds J L, Akhter J A, Magarey C J, Schwartz P, Adams W J, Morris D L
机构信息
Department of Surgery, University of New South Wales, St George Hospital, Kogarah, Australia.
出版信息
Br J Surg. 1998 Apr;85(4):538-41. doi: 10.1046/j.1365-2168.1998.00625.x.
BACKGROUND
Histamine inhibits lymphocyte function in vitro at concentrations of greater than 10(-6) mol/l. The aim of this study was to determine whether histamine concentrations in breast cancers were sufficient to produce an immunological effect.
METHODS
Tumour and adjacent normal breast content of histamine was measured using a radioenzymatic assay in 29 patients having surgery for breast cancer.
RESULTS
The median content of histamine in breast cancer tissue was 5.4 (range 0.9-27.3) microg/g (median concentration 4.5 x 10(-5) mol/l), and was significantly greater than that in adjacent breast tissue (P = 0.007).
CONCLUSION
The concentration of histamine in breast cancer was sufficient to inhibit lymphocyte function and could be locally immunosuppressive.
背景
组胺在体外浓度大于10⁻⁶mol/L时会抑制淋巴细胞功能。本研究的目的是确定乳腺癌中的组胺浓度是否足以产生免疫效应。
方法
采用放射酶法测定了29例接受乳腺癌手术患者的肿瘤及相邻正常乳腺组织中的组胺含量。
结果
乳腺癌组织中组胺的中位含量为5.4（范围0.9 - 27.3）μg/g（中位浓度4.5×10⁻⁵mol/L），显著高于相邻乳腺组织（P = 0.007）。
结论
乳腺癌中组胺的浓度足以抑制淋巴细胞功能，可能具有局部免疫抑制作用。
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