Oeser R, Pampel W, Mährlein W, Höpner S
Z Erkr Atmungsorgane. 1976 Apr;145(1):70-4.
122 patients, suspicious for silicoses, with a history of silicogen dust exposure, radiological changes and restricted lung function values were examined by mediastinal biopsy for securing the diagnosis. In 82 patients (67,2%) a silicosis could be confirmed by histological examinations of the mediastinal lymph nodes. A close association between silicosis in the lungs and in the lymph nodes is empirically suggested. If the histological findings were in compliance with suspicious radiological changes and patients history, silicosis was acknowledged as an occupational disease. In patients with beginning silicotic changes in the peripheral two upper lung fields associated with an hilar hyperplasia, a higher proportion of positive results could be found. The most positive alterations were found in the lymph nodes of the right hilus. The mediastinoscopical findings in other parts proved not to be so yielding. Therefore, in cases with anatomical difficulties the surgical examination should not be extended to other parts.
对122例疑似矽肺、有矽尘接触史、存在放射学改变及肺功能受限值的患者进行了纵隔活检以明确诊断。在82例患者（67.2%）中，通过纵隔淋巴结的组织学检查确诊为矽肺。根据经验提示，肺部矽肺与淋巴结矽肺之间存在密切关联。如果组织学检查结果与可疑的放射学改变及患者病史相符，则矽肺被认定为职业病。在周边两上肺野出现早期矽肺改变且伴有肺门增生的患者中，阳性结果的比例更高。最明显的改变见于右肺门淋巴结。在其他部位的纵隔镜检查结果显示阳性率不高。因此，在存在解剖困难的情况下，手术检查不应扩展至其他部位。
