The role of DNA repair in somatic hypermutation of immunoglobulin genes.
作者信息
Kim N, Storb U
机构信息
Department of, University of Chicago, Chicago, Illinois 60637, USA.
出版信息
J Exp Med. 1998 Jun 1;187(11):1729-33. doi: 10.1084/jem.187.11.1729.
Abstract
摘要
相似文献
1
The role of DNA repair in somatic hypermutation of immunoglobulin genes.DNA修复在免疫球蛋白基因体细胞超突变中的作用。
J Exp Med. 1998 Jun 1;187(11):1729-33. doi: 10.1084/jem.187.11.1729.
2
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting.MSH2基因缺陷小鼠中体细胞高频突变的热点聚焦表明突变靶向的两个阶段。
Immunity. 1998 Jul;9(1):135-41. doi: 10.1016/s1074-7613(00)80595-6.
3
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein.在缺乏错配修复蛋白MSH2的小鼠免疫球蛋白可变基因中，G和C核苷酸处的超突变增加。
J Exp Med. 1998 Jun 1;187(11):1745-51. doi: 10.1084/jem.187.11.1745.
4
Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern.MutS同源物（MSH）3、MSH6以及MSH3/MSH6缺陷小鼠中的体细胞超突变揭示了MSH2-MSH6异二聚体在调节碱基替换模式中的作用。
J Exp Med. 2000 Feb 7;191(3):579-84. doi: 10.1084/jem.191.3.579.
5
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation.错配识别和尿嘧啶切除为免疫球蛋白类别转换和体细胞突变的A/T集中阶段提供了互补途径。
Mol Cell. 2004 Oct 22;16(2):163-71. doi: 10.1016/j.molcel.2004.10.011.
6
Molecular mechanisms of antibody somatic hypermutation.抗体体细胞超突变的分子机制。
Annu Rev Biochem. 2007;76:1-22. doi: 10.1146/annurev.biochem.76.061705.090740.
7
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process.错配修复缺陷会干扰长期受刺激的B细胞中突变的积累，而不会干扰高突变过程。
Immunity. 1998 Jul;9(1):127-34. doi: 10.1016/s1074-7613(00)80594-4.
8
Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice.Bcl-2挽救生发中心反应，但不改变MSH2缺陷小鼠的V基因体细胞超突变谱。
J Immunol. 2002 Oct 1;169(7):3819-24. doi: 10.4049/jimmunol.169.7.3819.
9
Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination.Msh2 三磷酸腺苷酶活性对于α-T碱基对处的体细胞高频突变以及高效的类别转换重组至关重要。
J Exp Med. 2003 Oct 20;198(8):1171-8. doi: 10.1084/jem.20030880.
10
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.DNA修复缺陷小鼠记忆B细胞中免疫球蛋白基因的高突变
J Exp Med. 1998 Jun 1;187(11):1735-43. doi: 10.1084/jem.187.11.1735.
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Mutational patterns along different evolution paths of follicular lymphoma.滤泡性淋巴瘤不同进化路径中的突变模式。
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Mutating for Good: DNA Damage Responses During Somatic Hypermutation.有益突变：体细胞超突变过程中的 DNA 损伤反应。
Front Immunol. 2019 Mar 12;10:438. doi: 10.3389/fimmu.2019.00438. eCollection 2019.
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Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells.错配修复缺陷的造血干细胞是白血病前期干细胞。
PLoS One. 2017 Aug 2;12(8):e0182175. doi: 10.1371/journal.pone.0182175. eCollection 2017.
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Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cells.阳性共因子 4（PC4）对 DT40 细胞中 DNA 修复途径重路由至关重要。
Sci Rep. 2016 Jul 4;6:28890. doi: 10.1038/srep28890.
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MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils.MSH6 或 PMS2 缺陷导致 DT40 B 细胞中发生再复制，但对免疫球蛋白基因转换或 AID 产生的尿嘧啶的修复影响很小。
Nucleic Acids Res. 2013 Mar 1;41(5):3032-46. doi: 10.1093/nar/gks1470. Epub 2013 Jan 11.
6
Dimerization of MLH1 and PMS2 limits nuclear localization of MutLalpha.MLH1和PMS2的二聚化限制了MutLα的核定位。
Mol Cell Biol. 2003 May;23(9):3320-8. doi: 10.1128/MCB.23.9.3320-3328.2003.
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Somatic hypermutation in human B cell subsets.人类B细胞亚群中的体细胞高频突变
Springer Semin Immunopathol. 2001 Dec;23(4):367-85. doi: 10.1007/s281-001-8165-0.
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DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutation.高突变免疫球蛋白基因中的DNA断裂：体细胞超突变的断裂与修复途径的证据。
Genetics. 2001 May;158(1):369-78. doi: 10.1093/genetics/158.1.369.
9
Evolution and the molecular basis of somatic hypermutation of antigen receptor genes.抗原受体基因的体细胞高频突变的进化与分子基础。
Philos Trans R Soc Lond B Biol Sci. 2001 Jan 29;356(1405):67-72. doi: 10.1098/rstb.2000.0750.
10
Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.免疫球蛋白和非免疫球蛋白基因的体细胞超突变
Philos Trans R Soc Lond B Biol Sci. 2001 Jan 29;356(1405):13-9. doi: 10.1098/rstb.2000.0743.
本文引用的文献
1
Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.免疫球蛋白κ转基因内人工测试底物的体细胞高频突变。
J Immunol. 1998 Jul 15;161(2):782-90.
2
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2.DNA错配修复蛋白PMS2缺陷小鼠抗体中高突变的光谱改变。
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6953-8. doi: 10.1073/pnas.95.12.6953.
3
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein.在缺乏错配修复蛋白MSH2的小鼠免疫球蛋白可变基因中，G和C核苷酸处的超突变增加。
J Exp Med. 1998 Jun 1;187(11):1745-51. doi: 10.1084/jem.187.11.1745.
4
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.DNA修复缺陷小鼠记忆B细胞中免疫球蛋白基因的高突变
J Exp Med. 1998 Jun 1;187(11):1735-43. doi: 10.1084/jem.187.11.1735.
5
Mutation, selection, and memory in B lymphocytes of exothermic vertebrates.变温脊椎动物B淋巴细胞中的突变、选择和记忆
Immunol Rev. 1998 Apr;162:25-36. doi: 10.1111/j.1600-065x.1998.tb01426.x.
6
Evolution of somatic hypermutation and gene conversion in adaptive immunity.适应性免疫中体细胞超突变和基因转换的演变。
Immunol Rev. 1998 Apr;162:13-24. doi: 10.1111/j.1600-065x.1998.tb01425.x.
7
Somatic hypermutation of immunoglobulin genes is linked to transcription.免疫球蛋白基因的体细胞超突变与转录相关。
Curr Top Microbiol Immunol. 1998;229:11-9. doi: 10.1007/978-3-642-71984-4_2.
8
Mismatch repair co-opted by hypermutation.错配修复被高突变所利用。
Science. 1998 Feb 20;279(5354):1207-10. doi: 10.1126/science.279.5354.1207.
9
The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes.XP-C基因的失活不影响免疫球蛋白基因的体细胞超突变或类别转换重组。
Mol Immunol. 1997 May;34(7):527-33. doi: 10.1016/s0161-5890(97)00064-3.
10
Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers.人8-氧代鸟嘌呤DNA糖基化酶（MutM）基因在淋巴结生发中心暗区B淋巴细胞中的表达增强。
J Exp Med. 1997 Nov 3;186(9):1547-56. doi: 10.1084/jem.186.9.1547.
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