García-Ojeda M E, Dejbakhsh-Jones S, Weissman I L, Strober S
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
J Exp Med. 1998 Jun 1;187(11):1813-23. doi: 10.1084/jem.187.11.1813.
In the principal pathway of alpha/beta T cell maturation, T cell precursors from the bone marrow migrate to the thymus and proceed through several well-characterized developmental stages into mature CD4+ and CD8+ T cells. This study demonstrates an alternative pathway in which the bone marrow microenvironment also supports the differentiation of T cell precursors into CD4+ and CD8+ T cells. The marrow pathway recapitulates developmental stages of thymic maturation including a CD4+CD8+ intermediary cell and positive and negative selection, and is strongly inhibited by the presence of mature T cells. The contribution of the marrow pathway in vivo requires further study in mice with normal and deficient thymic or immune function.
在α/β T细胞成熟的主要途径中，来自骨髓的T细胞前体迁移至胸腺，并经过几个特征明确的发育阶段，分化为成熟的CD4+和CD8+ T细胞。本研究证明了另一条途径，即骨髓微环境也支持T细胞前体分化为CD4+和CD8+ T细胞。骨髓途径重现了胸腺成熟的发育阶段，包括CD4+CD8+中间细胞以及阳性和阴性选择，并且受到成熟T细胞的强烈抑制。骨髓途径在体内的作用需要在胸腺或免疫功能正常及缺陷的小鼠中进一步研究。
