Montero Alonso R, Barbadillo Izquierdo F, Ansó Oliván S, Marrero Calvo M, Carpintero Martín I, Sastre Huerta E, Alonso Alvarez B
Sección Neonatal (Servicio de Pediatría), Hospital General Yagüe, Burgos.
An Esp Pediatr. 1998 Mar;48(3):288-92.
Within the common pathogenic flora responsible for neonatal sepsis, streptococci group B (SGB) is the most frequently found etiological agent. The fact that it is a frequent colonizer of the female perigenital area has resulted in a whole host of detection and eradication strategies via preventative measures applied to the pregnant woman to eliminate vertical transmission to the newborn.
We present a revision of SGB sepsis and our protocol based on the intrapartum treatment of those pregnant women with risk factors and the study in the newborn at risk of infection with early detection of particles of Latex in urine for SGB (Slidex Strepto B bioMerieux), as well as the customary analytical and bacteriological tests. We have also revised the different strategies in medical scientific publications and several neonatal units for the management of this infection and compare this with our protocol.
During the period 1986-1996 the incidence of SGB sepsis was 0.9/1,000 (19 cases), with an incidence of neonatal sepsis of 4.08/1,000. The incidence of sepsis caused by Streptococcus agalactiae in our environment is low, although it has increased from 15.9% to 28% comparing the first five years with the following six years, with a fatality rate of 10.5%. We believe that the most effective strategy for this problem is intrapartum identification and treatment of the pregnant woman at risk and early diagnosis of the newborn resulting from this pregnancy.
We based our strategy on two vias, intrapartum treatment of mothers included in the high risk infection group and in the neonatal unit by early routine detection of SGB in urine. We have obtained a low incidence rate, low mortality rate and avoid false negatives of carrier mothers.
在引起新生儿败血症的常见病原菌中,B族链球菌(SGB)是最常见的病原体。由于它是女性生殖器周围区域的常见定植菌,因此产生了一系列检测和根除策略,通过对孕妇采取预防措施来消除垂直传播给新生儿。
我们介绍了SGB败血症及我们的方案,该方案基于对有危险因素的孕妇进行产时治疗,以及对有感染风险的新生儿进行研究,通过早期检测尿液中的SGB乳胶颗粒(生物梅里埃公司的链球菌B乳胶凝集试验)以及常规的分析和细菌学检测。我们还查阅了医学科学出版物和几个新生儿病房针对这种感染的不同管理策略,并将其与我们的方案进行比较。
1986年至1996年期间,SGB败血症的发病率为0.9/1000(19例),新生儿败血症的发病率为4.08/1000。在我们的环境中,无乳链球菌引起的败血症发病率较低,尽管与前五年相比,后六年从15.9%增加到了28%,死亡率为10.5%。我们认为解决这个问题最有效的策略是对有风险的孕妇进行产时识别和治疗,以及对由此妊娠产生的新生儿进行早期诊断。
我们的策略基于两条途径,即对高危感染组的母亲进行产时治疗,以及在新生儿病房通过早期常规检测尿液中的SGB。我们获得了低发病率、低死亡率,并避免了携带菌母亲的假阴性。