Müller-Ladner U, Gay R E, Gay S
Department of Internal Medicine I, University of Regensburg, Germany.
Curr Opin Rheumatol. 1998 May;10(3):212-9. doi: 10.1097/00002281-199805000-00010.
Molecular biology has provided various new insights into the mechanisms operative in the pathogenesis of rheumatoid arthritis. Reflecting the unique character of rheumatoid synovium, advances have been achieved addressing the molecular changes taking place at the area of interaction between the aggressively growing synovium and the articular cartilage and bone. Key issues in the review period addressing this interaction were hyperplasia of rheumatoid arthritis synovium, mechanisms of activation and cell cycle regulation of synovial fibroblasts, pathways of synovial attachment to cartilage and bone, and the regulation of matrix-degrading enzymes.
分子生物学为类风湿关节炎发病机制中的作用机制提供了各种新见解。鉴于类风湿滑膜的独特性质，在侵袭性生长的滑膜与关节软骨和骨之间相互作用区域发生的分子变化方面已取得进展。在本综述期间，针对这种相互作用的关键问题包括类风湿关节炎滑膜增生、滑膜成纤维细胞的激活机制和细胞周期调控、滑膜与软骨和骨的附着途径以及基质降解酶的调控。
