Screening of pharmaceuticals and drugs in synovial fluid of the knee joint and in vitreous humor by fluorescence polarization immunoassay (FPIA).

The investigations presented are aimed at testing whether ABBOTT's fluorescence polarization immunoassays for identification of drugs of abuse and pharmaceuticals in serum and urine are applicable to knee joint synovial fluid and vitreous humor. The survey confirms the general applicability of the tests to the respective body fluids without previous precipitation, only after liquefaction using hyaluronidase. The calculated cross-reactivities are shown in tables.