Pruzzo R, Amaral H, Morales B, Majlis S, Hurtado E
Unidad Medicina Nuclear, Clínica Alemana de Santiago, Chile.
Rev Med Chil. 1997 Oct;125(10):1182-6.
Parathyroid scintigraphy with Tc99m Sestamibi, a tracer that is taken up by hyperfunctioning parathyroid tissue, has a high yield in the diagnosis of abnormal parathyroid growths.
To assess the usefulness of parathyroid scintigraphy with Tc99m Sestamibi in patients with suspected hyperparathyroidism.
We analyzed retrospectively 29 patients with suspected hyperparathyroidism, in whom a scintigraphy with Tc99m Sestamibi was performed.
Twenty four of 25 patients in whom hyperfunctioning parathyroid tissue was evidenced with scintigraphy, were operated. Histological diagnosis of the excised parathyroid gland, showed 23 adenomas and 1 hyperplasia. Anatomical location disclosed by scintigraphy was concordant with surgical findings in all cases, including a mediastinic adenoma. Of the four patients with negative scintigraphic findings, two had transitory PTH elevations and in two the presence of adenoma or hyperplasia could not be demonstrated with other diagnostic procedures.
Parathyroid scintigraphy with Tc99m Sestamibi had an 86% sensitivity for the detection of hyperfunctioning parathyroid tissue in patients with elevated PTH.
使用锝99m甲氧基异丁基异腈进行甲状旁腺闪烁扫描，该示踪剂可被功能亢进的甲状旁腺组织摄取，在诊断甲状旁腺异常增生方面具有较高的检出率。
评估锝99m甲氧基异丁基异腈甲状旁腺闪烁扫描在疑似甲状旁腺功能亢进患者中的应用价值。
我们回顾性分析了29例疑似甲状旁腺功能亢进的患者，这些患者均接受了锝99m甲氧基异丁基异腈闪烁扫描。
25例经闪烁扫描证实存在功能亢进甲状旁腺组织的患者中，有24例接受了手术。对切除的甲状旁腺进行组织学诊断，结果显示23例为腺瘤，1例为增生。闪烁扫描显示的解剖位置与所有病例的手术结果一致，包括1例纵隔腺瘤。在4例闪烁扫描结果为阴性的患者中，2例甲状旁腺激素有短暂升高，另外2例经其他诊断方法未发现腺瘤或增生。
锝99m甲氧基异丁基异腈甲状旁腺闪烁扫描对甲状旁腺激素升高患者中功能亢进甲状旁腺组织的检测灵敏度为86%。
