Legato M J
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
Int J Fertil Womens Med. 1998 Mar-Apr;43(2):65-72.
Because most medical investigation traditionally has been restricted to men, many of our models of normal human physiology and of the pathophysiology of disease are skewed. The current interest in women's health has led us to concentrate on the differences between men and women; indeed, a survey of already published data reveals that there are significant variations in the normal function of virtually all the systems in the body. Furthermore, each of the sexes experiences disease differently in many important respects: coronary artery disease is a well-understood example of how gender determines the pathobiology of illness. As our understanding of the impact of gender on the mechanism of disease expands, our treatment of illness will become more focused and accurate. Sex-specific prescribing may well become the norm as the science of gender-specific medicine expands.
由于传统上大多数医学研究都局限于男性,我们许多关于正常人体生理学和疾病病理生理学的模型都存在偏差。当前对女性健康的关注促使我们关注男性和女性之间的差异;事实上,对已发表数据的一项调查显示,身体几乎所有系统的正常功能都存在显著差异。此外,在许多重要方面,两性患疾病的经历也有所不同:冠状动脉疾病就是一个很好的例子,说明了性别如何决定疾病的病理生物学。随着我们对性别对疾病机制影响的理解不断扩大,我们对疾病的治疗将变得更加有针对性和准确。随着性别特异性医学科学的发展,针对性别的开药很可能会成为常态。