Buckingham S C, Benaim E, Sandlund J T, Gan Y J, Freiden P J, Behm F G, Ribeiro R C, Sixbey J W, Slobod K S
Department of Infectious Disease, St Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.
Br J Haematol. 1998 May;101(2):345-8. doi: 10.1046/j.1365-2141.1998.00709.x.
Primary central nervous system lymphoma (PCNSL), observed among immunocompromised AIDS patients, has not been reported during chemotherapy for acute lymphoblastic leukaemia (ALL). We report a case of PCNSL occurring in a child receiving intensive multiagent chemotherapy for B-cell ALL. In situ hybridization studies demonstrated Epstein-Barr virus genome in both tumours, suggesting a possible link between the two diseases. The clinical response of the PCNSL to conservative therapy highlights the importance of accurately diagnosing such EBV-related disorders, especially in patients where immune compromise can be reversed.
