Lu F M, Chou C C, Chiang B L, Hsieh K H
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Republic of China.
Ann Allergy Asthma Immunol. 1998 May;80(5):419-23. doi: 10.1016/s1081-1206(10)62995-x.
The prevalence of allergic diseases such as asthma, allergic rhinitis, and atopic diseases has increased in recent years. Immunotherapy with allergens is a treatment documented to have an effect on regulating cytokine production and allergen-specific antibody production.
The aim of this study was to further investigate immunologic changes during immunotherapy and to explore the possible more efficient approach of immunotherapy.
Asthmatic children receiving house dust mite immunotherapy were followed to learn immunologic parameters such as allergen-specific antibody levels, proliferative response of peripheral blood mononuclear cells, and cytokine change during immunotherapy.
The data suggested (1) IgG4 anti-mite antibody increased 8 months after immunotherapy while IgE antibody level remained the same; (2) allergen-induced, in vitro production of certain cytokines such as IL-4 and IL-10 decreased after immunotherapy; (3) IL-13 (which can induce IgG4 and IgE antibody production by B cells) increased after immunotherapy.
Although this needs more study, IL-13 might play an important role in the generation of IgG4-blocking antibody during immunotherapy.
近年来，哮喘、过敏性鼻炎和特应性疾病等过敏性疾病的患病率有所上升。过敏原免疫疗法是一种已被证明对调节细胞因子产生和过敏原特异性抗体产生有作用的治疗方法。
本研究的目的是进一步研究免疫疗法期间的免疫变化，并探索可能更有效的免疫疗法方法。
对接受屋尘螨免疫疗法的哮喘儿童进行随访，以了解免疫疗法期间的免疫参数，如过敏原特异性抗体水平、外周血单个核细胞增殖反应和细胞因子变化。
数据表明：（1）免疫疗法8个月后，IgG4抗螨抗体增加，而IgE抗体水平保持不变；（2）免疫疗法后，过敏原诱导的某些细胞因子如IL-4和IL-10的体外产生减少；（3）免疫疗法后，IL-13（可诱导B细胞产生IgG4和IgE抗体）增加。
尽管这需要更多研究，但IL-13可能在免疫疗法期间IgG4阻断抗体的产生中起重要作用。
