Korystov Iu N, Shaposhnikova V V, Egorova M V
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
Izv Akad Nauk Ser Biol. 1998 Mar-Apr(2):200-3.
The mechanisms of signal triggering, enhancement and transduction during radiation-induced apoptosis of the thymocytes are discussed. Apoptosis is triggered by aggregation of receptors accompanied by activation of protein tyrosine kinases. The receptor aggregation is caused by radiation-induced cross-links. The signal is transduced to the gene from protein tyrosine kinase through Ras-proteins, protein kinase C, and transcription factors. The necessity of the lipoxygenase gene expression and synthesis of this enzyme for support and enhancement of the apoptotic signal is postulated.
本文讨论了辐射诱导胸腺细胞凋亡过程中信号触发、增强和转导的机制。凋亡是由受体聚集并伴随蛋白酪氨酸激酶激活而触发的。受体聚集是由辐射诱导的交联引起的。信号从蛋白酪氨酸激酶通过Ras蛋白、蛋白激酶C和转录因子转导至基因。推测脂氧合酶基因表达及该酶的合成对于支持和增强凋亡信号是必要的。
