Tsibulevskiĭ A Iu, Khripun A I, Ettinger A P, Dubovaia T K, Polivoda M D, Pen'kov L Iu
Russian State Medical University, Moscow, Russia.
Izv Akad Nauk Ser Biol. 1998 Mar-Apr(2):272-6.
We studied the role of parasympathetic division of vegetative nervous system in regulation of the intestine activity in rats subjected to bilateral subdiaphragmal vagotomy, the response of the neuromuscular apparatus of the small intestine to stimulation by aceclydine taken as an example. Intravenous injection of aceclydine (0.5 mg/kg) into intact animals is accompanied by characteristics changes in the electrical and contractile activities of the intestine, which reflect its enhanced motor activity. Vagotomy leads to changes of response of the intestine to pharmacological stimulation, most expressed within 3, 7, and 30 days. It was proposed that distortion of reactive properties of the intestine contractile system under these conditions is related to functional changes in rhythm-setting neurons of intramural ganglia and M-cholinoreceptors of neuromuscular synapses.
我们研究了自主神经系统副交感神经在双侧膈下迷走神经切断大鼠肠道活动调节中的作用，以小肠神经肌肉装置对醋甲胆碱刺激的反应为例进行研究。向完整动物静脉注射醋甲胆碱（0.5毫克/千克）会伴随肠道电活动和收缩活动的特征性变化，这反映了其运动活性增强。迷走神经切断术会导致肠道对药物刺激的反应发生变化，在3天、7天和30天内变化最为明显。有人提出，在这些情况下肠道收缩系统反应特性的改变与壁内神经节起搏神经元和神经肌肉突触的M胆碱能受体的功能变化有关。
