特比萘芬治疗甲真菌病的长期治疗后随访：一项多中心试验。

Long-term post-treatment follow-up of onychomycosis treated with terbinafine: a multicentre trial.

作者信息

Török I, Simon G, Dobozy A, Farkas B, Mészáros C, Nebenführer L, Szepes E, Tóth E

机构信息

Department of Dermato-Venereology, Semmelweis University of Medicine, Budapest, Hungary.

出版信息

Mycoses. 1998 Jan-Feb;41(1-2):63-5. doi: 10.1111/j.1439-0507.1998.tb00379.x.

DOI:10.1111/j.1439-0507.1998.tb00379.x

PMID:9610137

Abstract

Between 1991 and 1993, 32 cases of fingernail mycosis and 20 cases of toenail mycosis caused by dermatophytes were treated with terbinafine. For 8 weeks, 250 mg of terbinafine was given daily for fingernail infections, and for 12 weeks the same dose was given for toenail involvement; the short-term follow-up was 24 and 48 weeks respectively. A long-term follow-up was performed twice, initially at 24 and then at 48 months after the end of the treatment. For fingernail mycosis, the mycological cure rate was 100% at the end of month 24 and 91% at the end of month 48. Mycological cultures gave negative results in toenail infections in 90% after 24 months and in 86% after 48 months. After 24 months, 23 out of 26 patients (88%) with fingernail and 17 out of 20 patients (95%) with toenail mycosis were clinically cured. After 48 months, 20 out of 22 cases (91%) with fingernail and 10 out of 14 cases (71%) with toenail involvement showed a complete cure.

摘要

1991年至1993年期间，32例由皮肤癣菌引起的指甲癣和20例趾甲癣患者接受了特比萘芬治疗。对于指甲感染，连续8周每日给予250mg特比萘芬；对于趾甲感染，则连续12周给予相同剂量；短期随访分别为24周和48周。进行了两次长期随访，最初在治疗结束后24个月，然后在48个月。对于指甲癣，在第24个月末真菌学治愈率为100%，在第48个月末为91%。真菌培养显示，趾甲感染在24个月后90%呈阴性结果，48个月后86%呈阴性结果。24个月后，26例指甲癣患者中有23例（88%）临床治愈，20例趾甲癣患者中有17例（95%）临床治愈。48个月后，22例指甲受累患者中有20例（91%）完全治愈，14例趾甲受累患者中有10例（71%）完全治愈。