良性前列腺增生与男性型秃发的关联。

Association of benign prostatic hyperplasia with male pattern baldness.

作者信息

Oh B R, Kim S J, Moon J D, Kim H N, Kwon D D, Won Y H, Ryu S B, Park Y I

机构信息

Department of Urology, Chonnam University Medical School, Kwangju, South Korea.

出版信息

Urology. 1998 May;51(5):744-8. doi: 10.1016/s0090-4295(98)00108-3.

DOI:10.1016/s0090-4295(98)00108-3

PMID:9610587

Abstract

OBJECTIVES

Both benign prostatic hyperplasia (BPH) and male pattern baldness (androgenic alopecia) share the pathogenesis of an androgen-dependent disorder and afflict a large population of elderly men with chronobiologic progress. However, it is unclear whether these diseases are related epidemiologically. We evaluated the association of frequency and severity of male pattern baldness between patients with BPH and a control group.

METHODS

A total of 225 patients with BPH (mean age 69.3 +/- 6.5 years) and 1 60 controls (mean age 68.5 +/- 6.4 years), all over 60 years of age, were included in this study. The estimation of baldness severity was based on Norwood's classification (grade I to VII). The International Prostate Symptom Score (IPSS) and genetic tendency for baldness were also evaluated. The difference between IPSS and grade of baldness between the two groups was analyzed by the Mann-Whitney test and the frequency of inherited baldness was compared by the chi-square test. Correlation between severity of baldness and IPSS in each group was estimated by Spearman's rank correlation method.

RESULTS

The patients with BPH had an apparently higher grade of male pattern baldness in comparison with that of controls (median value of grade IV versus III, P <0.001). The proportion of men with male pattern baldness of grade IV or higher in the BPH group was significantly larger than that of controls (53.8% versus 36.9%, P <0.01). There was a greater frequency of inherited baldness in the BPH group than in the controls (31.6% versus 12.5%, P <0.001). No significant correlation was noted between baldness severity and IPSS in either group.

CONCLUSIONS

This study demonstrates a strong association of BPH with male pattern baldness.

摘要

目的

良性前列腺增生（BPH）和男性型秃发（雄激素性脱发）均为雄激素依赖性疾病，且随着年龄增长，影响着大量老年男性。然而，这两种疾病在流行病学上是否相关尚不清楚。我们评估了BPH患者与对照组男性型秃发的频率和严重程度之间的关联。

方法

本研究纳入了225例BPH患者（平均年龄69.3±6.5岁）和160例对照组（平均年龄68.5±6.4岁），所有患者年龄均超过60岁。秃发严重程度的评估基于诺伍德分类法（I级至VII级）。还评估了国际前列腺症状评分（IPSS）和秃发的遗传倾向。两组间IPSS和秃发等级的差异采用曼-惠特尼检验进行分析，遗传性秃发的频率采用卡方检验进行比较。每组中秃发严重程度与IPSS之间的相关性采用Spearman等级相关法进行评估。

结果

与对照组相比，BPH患者的男性型秃发等级明显更高（IV级中位数对III级，P<0.001）。BPH组中男性型秃发IV级或更高等级的男性比例显著高于对照组（53.8%对36.9%，P<0.01）。BPH组遗传性秃发的频率高于对照组（31.6%对12.5%，P<0.001）。两组中秃发严重程度与IPSS之间均未发现显著相关性。