Faydaci Gökhan, Bilal Eryildirim, Necmettin Penpegül, Fatih Tarhan, Asuman Orçun, Uğur Kuyumcuoğlu
Urology Clinic, Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey.
Aging Male. 2008 Dec;11(4):189-92. doi: 10.1080/13685530802400995.
We evaluated the pattern of baldness and serum androgen levels in patients with benign prostate hyperplasia (BPH) and prostate cancer. BPH, prostate cancer and androgenic alopecia (AA) were somehow androgen dependent and affect large population of elderly men.
A total of 152 patients, 108 patients with BPH and 44 patients with prostate cancer were included in the study. We measured serum total, free and bioavailable testosterone, FSH, LH, prolactin, estradiol, albumin and SHBG levels. Baldness classification was based on Norwood's classification and we categorised baldness as vertex and frontal baldness.
The frequency of AA in BPH and prostate cancer groups were not different. We looked for some correlation between the two groups with respect to AA and hormone levels. We did not find any correlation between AA and total testosterone, free testosterone, bioavailable testosterone or SHBG levels in both groups.
This prospective study with selected small group of patients showed that there is no difference of male pattern baldness in BPH and prostate cancer patients and also there is no correlation between pattern of baldness and serum androgen levels.
我们评估了良性前列腺增生(BPH)和前列腺癌患者的脱发模式及血清雄激素水平。BPH、前列腺癌和雄激素性脱发(AA)在某种程度上都依赖雄激素,且影响大量老年男性人群。
本研究共纳入152例患者,其中108例BPH患者和44例前列腺癌患者。我们检测了血清总睾酮、游离睾酮、生物可利用睾酮、促卵泡生成素(FSH)、促黄体生成素(LH)、催乳素、雌二醇、白蛋白和性激素结合球蛋白(SHBG)水平。脱发分类基于诺伍德分类法,我们将脱发分为头顶脱发和前额脱发。
BPH组和前列腺癌组中AA的发生率无差异。我们研究了两组在AA和激素水平方面的相关性。我们未发现两组中AA与总睾酮、游离睾酮、生物可利用睾酮或SHBG水平之间存在任何相关性。
这项针对一小部分选定患者的前瞻性研究表明,BPH患者和前列腺癌患者的男性型脱发无差异,且脱发模式与血清雄激素水平之间也无相关性。