特发性血栓栓塞作为隐匿性前列腺癌的首发症状。
Idiopathic thromboembolism as the presenting sign of occult prostate cancer.
作者信息
Oefelein M G, Brant M, Crotty K
机构信息
Wright-Patterson Medical Center, Wright-Patterson Air Force Base, Ohio 45414, USA.
出版信息
Urology. 1998 May;51(5):775-80. doi: 10.1016/s0090-4295(98)00008-9.
OBJECTIVES
Idiopathic thromboembolism has been associated with occult neoplasia; however, very limited information exists regarding a man's risk of occult prostate cancer after an idiopathic thromboembolic event.
METHODS
We performed a case-control study of 209 consecutive men diagnosed with prostate cancer over a 3-year period, with 350 men diagnosed with benign prostatic hyperplasia (BPH) serving as control subjects.
RESULTS
Men with idiopathic thromboembolism had a fivefold increased risk of prostate cancer compared with the BPH control group (risk ratio = 5.0, P = 0.002). The prostate-specific antigen (PSA) progression-free survival was not adversely affected after an idiopathic thromboembolic event.
CONCLUSIONS
Our data suggest that men with idiopathic thromboembolism are at an increased risk for being diagnosed with prostate cancer. In men with idiopathic thromboembolism, attempts to diagnose prostate cancer, including digital rectal examination and serum PSA, warrant consideration.
目的
特发性血栓栓塞与隐匿性肿瘤有关；然而，关于特发性血栓栓塞事件后男性患隐匿性前列腺癌的风险，现有信息非常有限。
方法
我们进行了一项病例对照研究，在3年期间连续纳入209例被诊断为前列腺癌的男性，350例被诊断为良性前列腺增生（BPH）的男性作为对照。
结果
与BPH对照组相比，特发性血栓栓塞男性患前列腺癌的风险增加了五倍（风险比=5.0，P=0.002）。特发性血栓栓塞事件后，前列腺特异性抗原（PSA）无进展生存期未受到不利影响。
结论
我们的数据表明，特发性血栓栓塞男性被诊断为前列腺癌的风险增加。对于特发性血栓栓塞男性，包括直肠指检和血清PSA在内的前列腺癌诊断方法值得考虑。
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