Massi D, Borgognoni L, Reali U M, Franchi A
Institute of Anatomic Pathology, University of Florence, Italy.
Melanoma Res. 1998 Apr;8(2):187-92. doi: 10.1097/00008390-199804000-00015.
A case of malignant melanoma arising in a young patient suffering from human immunodeficiency virus (HIV) infection is reported, along with a review of the literature. The neoplasm was characterized by aggressive clinical behaviour and, histopathologically, by a peculiar retiform pattern of growth with neoplastic cells interspersed among collagen bundles in the dermis without evident fibroplastic stromal reaction. In addition, a complete absence of host inflammatory cell infiltrate was noted. We hypothesize that this unusual histopathological pattern of growth, which has never been reported in this clinical setting, might be associated to HIV disease, immunosuppression and poor clinical outcome.
本文报告了一例发生在感染人类免疫缺陷病毒（HIV）的年轻患者身上的恶性黑色素瘤病例，并对相关文献进行了综述。该肿瘤的临床行为具有侵袭性，组织病理学表现为一种特殊的网状生长模式，肿瘤细胞散布于真皮层的胶原束之间，无明显的纤维母细胞基质反应。此外，还注意到完全没有宿主炎症细胞浸润。我们推测，这种从未在该临床背景下报道过的异常组织病理学生长模式，可能与HIV疾病、免疫抑制及不良临床预后有关。
