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用于交变梯度同步加速器放射生物学研究的1087兆电子伏特/核子铁-56束流的详细特性描述。

Detailed characterization of the 1087 MeV/nucleon iron-56 beam used for radiobiology at the alternating gradient synchrotron.

作者信息

Zeitlin C, Heilbronn L, Miller J

机构信息

Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

出版信息

Radiat Res. 1998 Jun;149(6):560-9.

PMID:9611094
Abstract

We report beam characterization and dosimetric measurements made using a 56Fe beam extracted from the Brookhaven National Laboratory Alternating Gradient Synchrotron (AGS) with a kinetic energy of 1087 MeV/nucleon. The measurements reveal that the depth-dose distribution of this beam differs significantly from that obtained with a 600 MeV/nucleon iron beam used in several earlier radiobiology experiments at the Lawrence Berkeley National Laboratory's BEVALAC. We present detailed measurements of beam parameters relevant for radiobiology, including track- and dose-averaged linear energy transfer (LET), fragment composition and LET spectra measured behind sample holders used in irradiations of biological samples. We also report measurements of fluence behind three depths (1.94, 4.68 and 9.35 g cm(-2)) of polyethylene targets with the 1087 MeV/nucleon beam, and behind 1.94 g cm(-2) of polyethylene with a 610 MeV/nucleon beam delivered by the AGS. These results are compared to earlier measurements with the 600 MeV/nucleon beam at the BEVALAC.

摘要

我们报告了使用从布鲁克海文国家实验室交变梯度同步加速器(AGS)提取的动能为1087 MeV/核子的56Fe束进行的束流特性表征和剂量测量。测量结果表明,该束流的深度剂量分布与劳伦斯伯克利国家实验室BEVALAC早期几个放射生物学实验中使用的600 MeV/核子铁束所获得的深度剂量分布有显著差异。我们给出了与放射生物学相关的束流参数的详细测量结果,包括径迹平均和剂量平均线能量转移(LET)、碎片组成以及在生物样品辐照中使用的样品架后面测量的LET谱。我们还报告了用1087 MeV/核子束在聚乙烯靶的三个深度(1.94、4.68和9.35 g cm⁻²)后面以及用AGS提供的610 MeV/核子束在1.94 g cm⁻²聚乙烯后面的注量测量结果。这些结果与BEVALAC早期用600 MeV/核子束进行的测量结果进行了比较。

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