Mariani B D, Tuan R S
Dept. of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Mol Med Today. 1998 May;4(5):207-13. doi: 10.1016/s1357-4310(98)80007-5.
The widespread use and dramatic success of prosthetic joint implant surgery (arthroplasty) has greatly improved the quality of life for many individuals suffering from degenerative, arthritic, or injured joints. However, in a number of cases, recipients experience discomfort at the arthroplasty site that can signal biomechanical failure, or periprosthetic infection of the joint, or both. In fact, infection remains a devastating obstacle, preventing arthroplasty from being an almost perfect medical procedure. Existing tests for the diagnosis of infection in orthopedics are disappointing because of the relatively high frequency of false negative results. To overcome this shortcoming, and to reduce the number of infected revision arthroplasties, a methodology based on molecular biology has been established. The method allows the rapid, sensitive and accurate diagnosis of orthopedic infections, and should aid the clinician with treatment regimens, surgical decisions, and overall patient management in the growing arthroplasty population.
人工关节置换手术（关节成形术）的广泛应用和巨大成功极大地改善了许多患有退行性、关节炎性或受伤关节的患者的生活质量。然而，在许多情况下，接受者在关节成形术部位会感到不适，这可能预示着生物力学失败、关节周围假体感染或两者皆有。事实上，感染仍然是一个毁灭性的障碍，使关节成形术无法成为近乎完美的医疗程序。由于假阴性结果的相对高发生率，现有的骨科感染诊断测试令人失望。为了克服这一缺点，并减少感染性翻修关节成形术的数量，已经建立了一种基于分子生物学的方法。该方法能够快速、灵敏且准确地诊断骨科感染，并应有助于临床医生对不断增加的关节成形术患者群体进行治疗方案制定、手术决策及整体患者管理。
