Ohta S, Watanabe Y, Nakajima T
Department of Public Health, Shinshu University School of Medicine, Matsumoto, Japan.
Prev Med. 1998 May-Jun;27(3):461-9. doi: 10.1006/pmed.1998.0298.
Whether alcohol consumption influences the development of hepatitis C in the presence of a latent infection needs to be determined.
The interaction between alcohol intake and hepatitis C virus infection with regard to development of liver injury was cross-sectionally investigated for 399 inhabitants of a town in Nagano Prefecture, Japan. In this town, the prevalence of hepatitis C virus infection is 32.4%.
The levels of indicators of liver function were significantly higher among subjects of both sexes who carried the antibody to hepatitis C virus than among those without the antibody. Among men, higher levels of liver function were more frequent among alcohol drinkers than among nondrinkers, suggesting that alcohol consumption may aid in the development of liver injury, even among subjects with a latent hepatitis C virus infection. gamma-Glutamyl transpeptidase activity was more sharply increased in relation to alcohol intake among subjects with hepatitis C virus infection than among those without it, suggesting that the presence of infection will influence alcohol-induced liver damage.
Alcohol consumption and a concomitant hepatitis C virus infection apparently facilitate the development of hepatitis.
需要确定在存在潜伏感染的情况下，饮酒是否会影响丙型肝炎的发展。
对日本长野县一个城镇的399名居民进行了横断面调查，研究饮酒与丙型肝炎病毒感染在肝损伤发展方面的相互作用。在这个城镇，丙型肝炎病毒感染的患病率为32.4%。
携带丙型肝炎病毒抗体的男女受试者的肝功能指标水平显著高于未携带抗体的受试者。在男性中，饮酒者的肝功能水平高于不饮酒者的情况更为常见，这表明饮酒可能有助于肝损伤的发展，即使在潜伏感染丙型肝炎病毒的受试者中也是如此。与未感染丙型肝炎病毒的受试者相比，感染丙型肝炎病毒的受试者中γ-谷氨酰转肽酶活性相对于饮酒量的增加更为明显，这表明感染的存在会影响酒精性肝损伤。
饮酒和同时感染丙型肝炎病毒显然会促进肝炎的发展。
