[乙醇和聚乙二醇-400对维拉帕米对蛙心肌变力作用频率依赖性的影响]
[Effect of ethanol and polyethylene glycol-400 on frequency dependence of the inotropic effect of verapamil on the frog myocardium].
作者信息
Nesterov V P, Korotkov S M, Matveev V V, Demina I N
机构信息
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., St. Petersburg, Russia.
出版信息
Ross Fiziol Zh Im I M Sechenova. 1998 Jan-Feb;84(1-2):111-4.
PMID:9612865
Abstract
The PEG-400 was found to be neutral in respect to the frequency-dependent V negative inotropic action whereas ethanol enhanced this dependence. The findings suggest a possibility for V inotropic activity to be modified by lipophilic agents, provided they sterically complementary to hydrophobic domains of the Ca2(+)-channel structure.
摘要
发现聚乙二醇400对频率依赖性V负性肌力作用呈中性，而乙醇增强了这种依赖性。这些发现表明，只要亲脂性药物在空间上与Ca2(+)通道结构的疏水结构域互补，就有可能改变V的肌力活性。
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