Khrapov K N, Shchegolev A V, Svistov D V, Baranenko Iu M
Anesteziol Reanimatol. 1998 Mar-Apr(2):40-3.
Effects of some methods of total anesthesia on the cerebral bloodflow and cerebrovascular reactivity was studied by transcranial dopplerography. Ketamine appreciably increases the cerebral bloodflow if no benzodiazepines are injected simultaneously. In patients with intracranial abnormalities ketamine can increase intracranial hypertension and disorder the cerebral perfusion. Despite the manifest hypotensive effect of diprivan, the autoregulation reserve of the cerebral bloodflow is not changed, probably due to the indirect vasoconstrictive effect of the drug. Total anesthesia with N2O and fentanyl virtually does not influence brain circulation.
通过经颅多普勒超声研究了某些全身麻醉方法对脑血流量和脑血管反应性的影响。如果不同时注射苯二氮䓬类药物，氯胺酮可显著增加脑血流量。对于颅内有异常的患者，氯胺酮可增加颅内压并扰乱脑灌注。尽管丙泊酚有明显的降压作用，但脑血流量的自动调节储备未改变，这可能是由于该药物的间接血管收缩作用。氧化亚氮和芬太尼全身麻醉实际上不影响脑循环。
