Tsutsumi M, Tsujiuchi T, Konishi Y
Department of Oncological Pathology, Cancer Center, Nara Medical University.
Nihon Rinsho. 1998 May;56(5):1234-8.
Telomerase activity and terminal restriction flagment (TRF) length were investigated in human and hamster pancreatic duct adenocarcinomas. In the hamster primary and transplantable pancreatic carcinomas and cell lines, telomerase activity increased 86 to 215.7 times relative to the levels in normal spleen and pancreas, and reduction of TRF length was observed. In 38 human pancreatic ductal carcinomas, 32 (84%) exhibited increased telomerase activities with no apparent relation to the histological type of tumor, tumor size, regional lymph node involvement and distant metastasis. These results suggest that telomerase play an important role for pancreatic duct carcinogenesis.
对人及仓鼠胰腺导管腺癌中的端粒酶活性和末端限制片段（TRF）长度进行了研究。在仓鼠原发性和可移植性胰腺癌及细胞系中，相对于正常脾脏和胰腺中的水平，端粒酶活性增加了86至215.7倍，并且观察到TRF长度缩短。在38例人胰腺导管癌中，32例（84%）表现出端粒酶活性增加，且与肿瘤的组织学类型、肿瘤大小、区域淋巴结受累及远处转移无明显关系。这些结果表明端粒酶在胰腺导管癌发生中起重要作用。
