Dam M, Christiansen J
Acta Neurol Scand. 1976 Sep;54(3):278-80. doi: 10.1111/j.1600-0404.1976.tb04804.x.
As the anticonvulsant plasma level of diazepam (DZP) after intravenous injection is maintained only for a short period, it is profitable to administer DZP as an intravenous infusion. It has, however, been claimed that DZP cannot be mixed with dextrose injection as DZP would precipitate. As this is in contrast to our clinical experience we added DZP of various brands to dextrose injections. A precipitate was in fact found in dextrose injections containing Valium and Stesolid whereas Diazepam A.L. was not only slightly cloudy. The concentration of DZP was, however, the same in all the samples and corresponded to the calculated concentration. The precipitate in the solutions with Valium and Stesolid which did not pass the filter must therefore be due to additives, most probably benzoates. On the basis of these findings and our clinical experience of this mode of administration we recommend the infusion method as one of the most effective in the acute treatment of status epilepticus.
由于静脉注射后地西泮（DZP）的抗惊厥血浆水平仅能维持较短时间，因此将地西泮作为静脉输注给药是有益的。然而，有人声称地西泮不能与葡萄糖注射液混合，因为地西泮会沉淀。由于这与我们的临床经验相反，我们将不同品牌的地西泮添加到葡萄糖注射液中。事实上，在含有安定和速眠安的葡萄糖注射液中发现了沉淀，而安定A.L.只是略显浑浊。然而，所有样品中地西泮的浓度相同，且与计算浓度相符。因此，含有安定和速眠安且未通过过滤器的溶液中的沉淀必定是由添加剂引起的，很可能是苯甲酸盐。基于这些发现以及我们对这种给药方式的临床经验，我们推荐输注法作为癫痫持续状态急性治疗中最有效的方法之一。
