双相情感障碍患者中寻求新奇行为与多巴胺D3受体基因的关联：一项初步报告。

Association between novelty-seeking and the dopamine D3 receptor gene in bipolar patients: a preliminary report.

作者信息

Staner L, Hilger C, Hentges F, Monreal J, Hoffmann A, Couturier M, Le Bon O, Stefos G, Souery D, Mendlewicz J

机构信息

Department of Psychiatry, Centre Hospitalier de Luxembourg, Grand Duchy of Luxembourg.

出版信息

Am J Med Genet. 1998 Mar 28;81(2):192-4.

PMID:9613861

Abstract

Recent studies in healthy controls suggest an association between novelty-seeking (NS) and the dopamine D4 receptor (DRD4) gene. In this study, we further investigated the relationship between genes implicated in dopamine as well as serotonin neurotransmission and personality traits in bipolar (BP) disorder. Scores on the Tridimensional Personality Questionnaire were examined in 37 recovered Research Diagnostic Criteria-diagnosed BP patients genotyped for DRD3, DRD4, and serotonin 2A receptor (5HTR2a) polymorphisms. Carriers of DRD3 allele 1 showed significantly lower NS values compared to patients without this allele. Scores on NS and on harm-avoidance were not related to DRD4 or 5HTR2a polymorphisms. These preliminary results suggest a role for D3 receptor in NS expression in BP patients.

摘要

近期针对健康对照人群的研究表明，寻求新奇感（NS）与多巴胺D4受体（DRD4）基因之间存在关联。在本研究中，我们进一步探究了与多巴胺以及5-羟色胺神经传递相关的基因与双相情感障碍（BP）患者人格特质之间的关系。对37名康复的、经研究诊断标准确诊为双相情感障碍的患者进行了三维人格问卷评分检测，这些患者均已进行DRD3、DRD4和5-羟色胺2A受体（5HTR2a）基因多态性分型。与未携带该等位基因的患者相比，携带DRD3等位基因1的患者NS值显著更低。NS评分和回避伤害评分与DRD4或5HTR2a基因多态性无关。这些初步结果表明，D3受体在双相情感障碍患者的NS表达中发挥作用。