University of California, San Diego, United States; VA Center of Excellence in Stress and Mental Health, United States.
University of California, San Diego, United States.
Psychiatry Res. 2022 Oct;316:114776. doi: 10.1016/j.psychres.2022.114776. Epub 2022 Aug 7.
Novelty seeking is a tendency to approach new situations, putatively driven by the brain's catecholaminergic system. It is traditionally measured via self-report, but a laboratory-based paradigm, the human Behavioral Pattern Monitor (hBPM), quantifies behavior in a novel environment and has utility in cross-species studies of neuropsychiatric disorders. Our primary aim assessed whether self-reported novelty-seeking traits were associated with novelty-seeking behavior in the hBPM. An existing sample of 106 volunteers were categorized as high vs. low novelty seekers using the Temperament and Character Inventory (TCI). Subjects had been randomized to one dose of amphetamine (10 or 20 mg) or modafinil (200 or 400 mg), allowing us to explore whether a pharmacological catecholamine challenge further enhanced novelty-seeking behavior. High TCI novelty-seekers had more hBPM motor activity and novel object interactions. The exploratory analyses, although limited by low power, suggested that amphetamine and modafinil did not markedly moderate novelty-seeking traits. The hBPM demonstrates construct validity as a lab-based measure of novelty seeking and thus useful in translational studies of neuropsychiatric conditions and treatment options. Further research may illuminate whether a biological predisposition towards higher catecholaminergic activity, combined with the novelty-seeking trait, may increase propensity for risky and addictive behaviors.
寻求新奇是一种接近新情况的倾向，据推测是由大脑的儿茶酚胺能系统驱动的。它传统上通过自我报告来测量，但一种基于实验室的范式，即人类行为模式监测器（hBPM），可以量化新环境中的行为，并在神经精神障碍的跨物种研究中具有实用性。我们的主要目的是评估自我报告的寻求新奇特质是否与 hBPM 中的寻求新奇行为相关。使用气质和性格量表（TCI），对 106 名现有志愿者进行了高与低寻求新奇特质的分类。受试者被随机分配接受安非他命（10 或 20mg）或莫达非尼（200 或 400mg）的一剂治疗，这使我们能够探索药理学儿茶酚胺挑战是否进一步增强了寻求新奇的行为。高 TCI 寻求新奇者在 hBPM 中的运动活动和新物体互动更多。虽然探索性分析受到低功效的限制，但结果表明安非他命和莫达非尼并没有明显调节寻求新奇特质。hBPM 作为一种基于实验室的寻求新奇的测量方法，具有结构有效性，因此可用于神经精神疾病和治疗选择的转化研究。进一步的研究可能阐明，较高的儿茶酚胺能活动的生物学倾向，加上寻求新奇特质，是否会增加冒险和成瘾行为的倾向。
