一名接受氟达拉滨治疗的华氏巨球蛋白血症患者并发隐球菌性脑膜炎和颅内结核瘤

Cryptococcal meningitis and intracranial tuberculoma in a patient with Waldenstrom's macroglobulinemia treated with fludarabine.

作者信息

Costa P, Luzzati R, Nicolato A, Perboni G, Scalzini A, Lazzarini L, Forghieri M E, Aitini E, Zinzani P L

机构信息

Department of Infectious Diseases, Ospedale C. Poma, Mantova, Italy.

出版信息

Leuk Lymphoma. 1998 Feb;28(5-6):617-20. doi: 10.3109/10428199809058373.

DOI:10.3109/10428199809058373

PMID:9613995

Abstract

We report a patient with Waldenstrom's Macroglobulinemia who presented with cryptococcal meningitis followed by an intracranial tuberculoma during the 18 months period after termination of cytotoxic therapy with Fludarabine. Opportunistic infections due to intracellular organisms are extremely rare in the course of this malignancy and we review the predisposing factors of these infectious entities.

摘要

我们报告一例华氏巨球蛋白血症患者，在使用氟达拉滨进行细胞毒性治疗结束后的18个月期间，先是出现了隐球菌性脑膜炎，随后又出现了颅内结核瘤。在这种恶性肿瘤病程中，由细胞内病原体引起的机会性感染极为罕见，我们回顾了这些感染性疾病的易感因素。