Melander A, Danielson K, Hanson A, Jansson L, Rerup J C, Scherstén B, Thulin T, Wåhlin E
Acta Med Scand. 1976;200(1-2):93-97. doi: 10.1111/j.0954-6820.1976.tb08202.x.
The influence of food intake on the bioavailability of isoniazid (INH) has been examined in nine healthy male volunteers. INH was administered as a single oral dose, both in fasting state and together with a standardized breakfast. Numerous venous blood samples were obtained 5 min-6 hours after the INH ingestion, and the concentrations of unmetabolized INH in serum were assessed by spectrophotometry. The observations indicate that both the peak concentration and the total amount of INH absorbed are greatly reduced when the drug is ingested together with food. Hence it is recommended that, in the treatment of tuberculosis with INH, the drug should be given on an empty stomach. The data may also have some bearing on the use of INH for assessing acetylation rates and estimating dosages of hydralazine and related drugs.
在9名健康男性志愿者中研究了食物摄入对异烟肼（INH）生物利用度的影响。异烟肼以单次口服剂量给药，分别在空腹状态下以及与标准化早餐一起服用。在摄入异烟肼后5分钟至6小时采集了多份静脉血样，并通过分光光度法评估血清中未代谢异烟肼的浓度。观察结果表明，当药物与食物一起摄入时，异烟肼的峰值浓度和吸收总量均大幅降低。因此，建议在使用异烟肼治疗结核病时，应空腹给药。这些数据可能也与使用异烟肼评估乙酰化率以及估算肼屈嗪及相关药物的剂量有关。
