Suryawati S, Santoso B
Int J Clin Pharmacol Ther Toxicol. 1986 Jan;24(1):18-22.
Measurements of isoniazid (INH) half-lives from salivary samples were conducted in 8 healthy volunteers. The study showed a significant positive correlation between salivary and serum INH concentrations (rs = 0.92, n = 50) with the mean saliva/serum concentration ratio of 0.81 (+/- s. e. m. 0.05). The correlation in INH concentration between salivary and serum samples obtained during the elimination phase (rs = 0.92, n = 50) was greater than that obtained during the absorption phase (rs = 0.71, n = 18). The measurements of INH half-lives from salivary samples were very close to those from serum (rs = 0.95, n = 8), and no misclassification into either phenotype was made by using salivary INH half-life for acetylator phenotyping, compared to that by using serum samples. It was concluded, therefore, that INH half-life measurement from saliva could be used as a reliable and convenient method for acetylator phenotyping. However, the calculation of absorption kinetic parameter, of clearance and of the volume of distribution of INH by using salivary samples could not be justified.
对8名健康志愿者的唾液样本进行了异烟肼（INH）半衰期的测量。研究表明，唾液和血清中INH浓度之间存在显著正相关（rs = 0.92，n = 50），唾液/血清浓度平均比值为0.81（±标准误0.05）。消除期获得的唾液和血清样本中INH浓度的相关性（rs = 0.92，n = 50）大于吸收期获得的相关性（rs = 0.71，n = 18）。唾液样本中INH半衰期的测量值与血清测量值非常接近（rs = 0.95，n = 8），与使用血清样本相比，使用唾液INH半衰期进行乙酰化酶表型分析时，没有出现任何表型误分类情况。因此得出结论，唾液中INH半衰期的测量可作为一种可靠且便捷的乙酰化酶表型分析方法。然而，利用唾液样本计算INH的吸收动力学参数、清除率和分布容积是不合理的。
