易位(3;13)(q27;q14)：非霍奇金淋巴瘤中的一种非随机且可能为继发性的结构改变。

Translocation (3;13)(q27;q14): a nonrandom and probably secondary structural change in non-Hodgkin lymphomas.

作者信息

Laï J L, Daudignon A, Kerckaert J P, Galiègue-Zouitina S, Detourmignies L, Morel P, Bauters F, Fenaux P

机构信息

Service de Génétique Médicale, Hôpital Jeanne de Flandre, Lille, France.

出版信息

Cancer Genet Cytogenet. 1998 Jun;103(2):140-3. doi: 10.1016/s0165-4608(97)00391-9.

DOI:10.1016/s0165-4608(97)00391-9

PMID:9614913

Abstract

Three cases of (3;13)(q27;q14) translocation observed in different histological types of non-Hodgkin lymphomas (NHLs) are reported here. This new recurring translocation in NHL was secondary in at least two of the patients because it was associated with another specific change [i.e., t(8;14) (q24;q32) in Burkitt lymphoma and t(14;18)(q32;q21) in typical follicular lymphoma]. In two of the cases for which molecular analysis was performed, a rearrangement of the LAZ-3/BCK-6 gene was found.

摘要

本文报道了在不同组织学类型的非霍奇金淋巴瘤（NHL）中观察到的3例（3；13）（q27；q14）易位。这种在NHL中新出现的复发性易位在至少两名患者中是继发性的，因为它与另一种特定变化相关[即，伯基特淋巴瘤中的t（8；14）（q24；q32）和典型滤泡性淋巴瘤中的t（14；18）（q32；q21）]。在进行分子分析的两例病例中，发现了LAZ-3/BCK-6基因重排。