与青霉素相互作用的酶的X射线研究。
X-ray studies of enzymes that interact with penicillins.
作者信息
Kelly J A, Kuzin A P, Charlier P, Fonzé E
机构信息
Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA.
出版信息
Cell Mol Life Sci. 1998 Apr;54(4):353-8. doi: 10.1007/s000180050163.
Abstract
The technique of X-ray diffraction has been successfully applied to enzymes associated with peptidoglycan biosynthesis. The technique has taught us a great deal about the structures and catalytic mechanisms of penicillin-binding proteins and beta-lactamases. An insight into the structural basis for antibiotic resistance is given.
摘要
X射线衍射技术已成功应用于与肽聚糖生物合成相关的酶。该技术让我们对青霉素结合蛋白和β-内酰胺酶的结构及催化机制有了很多了解。它为抗生素耐药性的结构基础提供了深入见解。
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