Sendo T, Hirakawa M, Yaginuma M, Aoyama T, Oishi R
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Acad Radiol. 1998 Jun;5(6):444-7. doi: 10.1016/s1076-6332(98)80032-9.
The authors compared the particle contaminations of radiographic contrast media packaged in large-volume prefilled syringes and vials.
Particle counting was performed for four contrast media packaged in large-volume prefilled syringes (iohexol, ioversol, ioversol for angiography, and ioxaglate) and three contrast media packaged in vials (iohexol, ioversol, and ioxaglate). X-ray emission spectrometry was performed to characterize the individual particles. The amount of silicone oil in the syringe was quantified with infrared spectrophotometry.
The particle contamination in syringes containing ioversol was higher than that in syringes containing iohexol or ioxaglate. Particle contamination in the vials was relatively low, except with ioxaglate. X-ray emission spectrometry of the components of the syringe and vial showed that the source of particles was internal material released from the rubber stopper or inner surface.
The particle counts for contrast media packaged in syringes and vials varied considerably among the different contrast media and were related to the amount of silicone oil on the inner surface and rubber piston of the syringe.
作者比较了大容量预填充注射器和小瓶包装的放射造影剂的颗粒污染情况。
对四种大容量预填充注射器包装的造影剂（碘海醇、碘佛醇、血管造影用碘佛醇和碘克沙醇）和三种小瓶包装的造影剂（碘海醇、碘佛醇和碘克沙醇）进行颗粒计数。采用X射线发射光谱法对单个颗粒进行表征。用红外分光光度法定量注射器中的硅油含量。
含碘佛醇的注射器中的颗粒污染高于含碘海醇或碘克沙醇的注射器。小瓶中的颗粒污染相对较低，但碘克沙醇除外。注射器和小瓶成分的X射线发射光谱显示，颗粒来源是从橡胶塞或内表面释放的内部材料。
注射器和小瓶包装的造影剂的颗粒计数在不同造影剂之间差异很大，并且与注射器内表面和橡胶活塞上的硅油含量有关。
